Confidential Client – Vector Suite for Non-Antibacterial Beta-Lactams

Precis provided the architectural and engineering design for the development of a new non-antibacterial beta-lactams drug production suite. The project included the 4,000-sf fit-out of an existing manufacturing suite to be used for a revised manufacturing process. Design included the modification of a primary packaging line for a more robust dust collection.

Precis did the original engineering design for the suite in 2007. For this project, Precis was competitively contracted for the preliminary design study. Upon client satisfaction with the work provided in the study, additional sole-source awards were given to Precis for the detailed design and construction administration.

The project included multiple design hurdles that Precis overcame through planning and close coordination with the client. The largest hurdle was the adjacent manufacturing suites sharing a corridor with an ezetimibe suite, as well as the ezetimibe suite and an adjacent suite sharing a mechanical corridor and mezzanine that required separation for a monobactam manufacturing facility. Precis was able to provide new layouts to meet the requirements of the space and designed dedicated material airlocks between the ezetimibe suite and common clean corridor. Precis worked with the client to complete several conceptual design iterations before participating in the FMEA to determine the ultimate design for construction that best suited the client’s needs.

All design options carefully considered construction cost and attempted to minimize modifications to the existing space layouts while still providing the required elements for containment and proper material and personnel flows to meet strict isolation requirements for product manufacturing. This included the transition of a bubble-type suite to a cascade. Precis’ deep understanding of clean spaces and manufacturing standards allowed for innovative solutions that ensured compliance while optimizing operational efficiency.