Frontage Laboratories, Inc. – Sierra Drive Fit-Out

Frontage Laboratories is a global pharmaceutical development organization (PDO) advancing drug discovery and development. Precis provided architecture and mechanical, electrical, plumbing, fire protection, and process engineering design services for the relocation and expansion of Frontage’s existing pilot scale production facility into a new building. The expansion was designed to support Phase I and Phase II Clinical Products.

Design for the fit-out encompassed approximately 46,000 sf. A non-sterile area includes five ISO 8 processing suites for multi-product processing of non-sterile products, including oral solid dosage (OSD), ointments, liquids, etc. A sterile area consists of two sterile filling suites for multi-product processing of sterile products into vials, syringes, and bottles. Each filling suite is ISO 7 with an interior ISO 5 area for filling. Additional ISO 7 spaces included sterile equipment staging and material (MAL) and personnel (PAL) airlocks. A potent compound area consists of two potent suites for occupational exposure band (OEB) Category 3 – occupational exposure limit (OEL) 50 to 100 ug/m3 compounds. The suite has unidirectional MAL and PAL airlocks with a misting shower for PAL out. Support areas include analytical and microbiology labs, equipment wash, clean equipment staging, a GMP warehouse, mechanical rooms, and offices.

During the design phase, the shell of the space was under construction, resulting in an early underground/slab package being issued to keep the construction team progressing. Long-lead equipment specifications were identified and fast-tracked for early procurement. These early packages enabled the design team to develop the detailed design while the construction team concurrently procured the long-lead equipment and installed underground plumbing.