Piramal Pharma Solutions – Fill/Finish Manufacturing Facility Expansion

Piramal Pharma Solutions is a leading global contract development and manufacturing organization (CDMO). Precis provided architecture, process architecture, and mechanical, electrical, plumbing, fire protection, and process engineering design services for interior renovations and facility expansion of Piramal’s Lexington fill/finish manufacturing facility. Situated on a 12-acre site, the facility had sufficient land area to expand the existing building’s footprint and site features to meet the current need for expanded fill/finish capacity.

The 16,000-sf expansion included a Grade C fill/finish suite with associated Grade C support areas and Grade D equipment staging and clean-in-place (CIP) and sterilize-in-place (SIP) rooms. Renovations to the existing building included a 2,600-sf microbiology lab suite with CNC laboratory and support areas, Grade D gowning rooms, and a Grade C sterility testing room.

Additional support spaces included a new production staff office suite, new toilet areas, and upgrades to the existing unisex changing rooms. New mechanical equipment and building utilities were provided on a new mechanical mezzanine above the production area expansion, within the existing mechanical rooms, clean utility room, and outside adjacent to the building.

Additionally, Piramal requested the design of 12 new, temporary cold boxes and a connecting corridor as well as design for a new building connection from their existing building to the temporary cold box corridor.