cGMP Warehouse
Precis provided full architecture, mechanical, electrical, plumbing, fire protection, and process engineering services for the multi-phase design and engineering of a new off-site cGMP warehouse and storage facility for a global contract research development and manufacturing organization (CRDMO) in New Jersey.
Supporting services for the client’s existing facility in a nearby town were also provided. The remaining shell space fit-out will include a new modular-construction drug product fill/finish suite, cell bank suite, product sample suite, and various cold storage amenities. The existing two-story 14,000-sf front office underwent minor renovations to accommodate a new workspace, which required a new 650-sf quality control (QC) laboratory.
Jefferson Institute for Bioprocessing – Lab Expansion
The Jefferson Institute for Bioprocessing (JIB) is the first specialized North American institute for biopharmaceutical processing with single-use processing equipment. Precis helped JIB evaluate various expansion options prior to defining an optimal approach that addressed training and research needs within the cost parameters of the organization. The expansion project converted approximately 5,000 sf of office space within the existing facility to laboratory space that expanded JIB’s already functioning Flex Factory.
A new analytical lab provides a full complement of research and testing capabilities along with nine lab trainee workstations. One gene therapy lab and three cell therapy labs support JIB’s process development programs. Planned for flexible operations, this cell and gene therapy lab suite is designed and constructed to Biosafety Level 2 (BSL-2) standards as required with cell culture research. New HVAC systems were provided to support the strict lab requirements, and the area incorporated flush, cleanable finishes to promote lab cleanliness.
The expansion enhances JIB’s well-regarded presence and serves to further project JIB’s influence throughout the regional life science and biotech community.
Subbio Medical Spa – Expansion + Renovation
Subbio Plastic Surgery & Medical Spa underwent a transformation and expansion into an adjacent 5,000-sf building, featuring a full interior and exterior renovation. Precis provided comprehensive architectural planning and design of the new space. The vision behind the project was to create a bold, modern presence along the busy roadway, making the medical spa an eye-catching landmark while enhancing the client experience within. The project is more than a renovation – it’s a reimagining of the client experience, blending luxury, innovation, and artistry in one exceptional environment.
The one-story structure underwent complete modernization with a full recladding, complemented by the addition of new windows that flood the interior with natural daylight. The dramatic changes revitalized the building’s façade and redefined its identity with a statement of contemporary elegance and sophistication.
Seamlessly integrated with the existing medical facility, the new interior space is designed to feel open, bright and inviting. A reception area welcomes guests with an open layout that allows natural light to flow from multiple directions, enhancing the sense of warmth and tranquility. The design strikes a balance between modern elegance and inviting comfort, incorporating rich wood tones in custom wood slat-wall designs, contrasting with cooler gray hues in a custom poured-epoxy floor and bright white walls. Beyond its function as a state-of-the-art medical spa, the space is an artistic expression of Dr. Subbio – a renowned plastic surgeon in the Philadelphia area and a talented artist. The corridor walls leading to the treatment rooms are painted bright white and designed as a gallery space, featuring track lighting to showcase future custom artwork created by Dr. Subbio. This personal touch brings a unique dimension to the spa, transforming it into both a wellness sanctuary and a creative exhibition.
The expanded medical spa includes three new treatment rooms, three Botox rooms, a massage and facial room, a hyperbaric chamber, and a LED light therapy room. The spa also gained an additional large office area with private offices, open workstations, and a training room for live presentations and webinars.
Century Therapeutics – Corporate Headquarters + Laboratory Consolidation Fit-Out
Precis provided mechanical, electrical, plumbing, and fire protection engineering services in support of an 80,000-sf corporate headquarters and laboratory consolidation fit-out for Century Therapeutics, a biotechnology company that engages in the development of genetically engineered allogeneic cell therapies for the treatment of solid tumor and hematological malignancies.
The project scope encompassed the 11th, 12th and 13th floors of the One uCity Square building in Philadelphia, Pennsylvania. The space is occupied by 60 percent general laboratory space and 40 percent office, amenity, and circulation space. The program included corporate headquarters administrative and showcase customer areas; analytical, quality assurance/quality control (QA/QC), and product development laboratories; and laboratory support functions.
The engineering scope included review of existing utility systems to determine the adequacy of the existing base building electrical service, HVAC, sanitary, and plumbing utilities to support the new lab and office layouts. System upgrades were performed based on the initial review. Construction administration services were also provided.
Children’s Hospital of Philadelphia – High Level Disinfection Suite Renovations
Precis provided architecture and engineering design services for renovations to multiple high-level disinfection (HLD) suites in Children’s Hospital of Philadelphia (CHOP). The renovations were required to bring the HLD suites up to current industry standards to reduce cross-contamination during the post-procedure instrument cleaning process.
The scope involved a comprehensive assessment and redesign of the existing spaces to accommodate the latest disinfection technologies and protocols. The project aimed to enhance patient safety by improving the efficiency and reliability of the sterilization process. The layout was optimized to facilitate smooth workflows and provide ample storage space for disinfection supplies. Workstations were designed to support the meticulous handling and tracking of instruments.
National Refrigerants, Inc. – New Flammables Packaging and Storage Building
Precis provided architectural and mechanical, electrical, fire protection, plumbing, structural, and civil engineering design services for a packaging and storage building for National Refrigerants (NRI). The new building needed to include approximately 25,000 sf for flammable packaging and approximately 75,000 sf for flammable product storage. The building was designed and constructed to meet hazardous occupancy requirements as dictated by the building code for handling of flammable materials.
Design features included one flammable can line and three flammable packaging lines; outside storage tanks plus additional space for expansion; ISO storage area and storage racking; warehouse and administrative offices and restroom facilities; recovery lab and GCs; foundations for a gas house shed, bulk storage tank, and FT/WT structures; HVAC rooftop units; miscellaneous piping supports between the new building and bulk storage area; fire protection, including on-site fire water storage tank, pump house, riser room, and sprinkler systems; approximately 10 loading docks with doors, bumpers, and dock plates; and stormwater management and erosion and sediment control.
Teva Pharmaceuticals – Distribution Center Campus
Precis completed full mechanical, electrical, plumbing, and fire protection design for a new pharmaceutical distribution center campus planned for global biopharmaceuticals company, Teva Pharmaceuticals Ltd. The program was spread across three buildings and 136 acres and included a cGMP warehouse, pick and pack distribution center, administrative offices, an information technology data center, and a central utility plant.
Precis provided comprehensive engineering design for a 120-foot high-bay automated storage and retrieval system (ASRS); complete distribution center building systems with complex material handling systems, including pick modules, full case mini-load, broken case mini-load, commissioner, sorter, parcel build stations, launch pack stations, refrigerator pick modules and pack stations, and pallet and carton conveyors; a Drug Enforcement Administration (DEA) validated security vault, a caged area for storing DEA controlled substances, and a large vendor-supplied refrigerator to store product between 2-8 degrees C. The facility central plant design included a 4,500-ton chilled water plant, a 2,000-HP hot water heating plant and all campus distribution, and a U.S. National Data Center. Design included 3D computational fluid dynamics (CFD) modeling for detailed analysis of temperature distribution, including modeling of the 120-foot-high ASRS and 40-foot-high distribution areas.
Renaissance Pharma, Inc. – Grade C Compounding + Filling Suites
Precis supported expansion of the existing Grade C filling capabilities to support a manufacturing contract for compounding, filling, and packaging a bio-dosage nasal product with a potent active pharmaceutical ingredient (API). The project renovated existing process areas to create two new filling suites and one compounding suite, with associated technical support spaces. In addition, an existing secondary packaging area was enclosed to control access to new secondary packaging equipment.
Two compounding scale stations were incorporated into the design, each equipped with a pit scale and utility panel with process vent, vacuum, water for injection (AWFI), clean steam, clean steam condensate, compressed air (30 psig and 90 psig), nitrogen (two at 30 psig), process waste, tempered chilled water supply and return from a telematics control unit (TCU) (one with chilled water supply and return), and a local human-machine interface (HMI) for TCU control to support compounding in vessels up to 250L. One of the two compounding stations was designed for future use of solvents.
The project utilized pre-engineered modular wall and ceiling panels with honeycomb core and PVC coating and an epoxy urethane floor system with an integral cove base integrated with the modular wall panels. The cleanroom walkable ceiling is connected to the existing mezzanine about this area. An elevated steel-framed system was provided to support a mezzanine extension or catwalk system. An elevated steel dunnage platform extension above the existing roof was provided to house the new chilled water, process chilled water, and air systems infrastructure.
Lannett Company – Office Fit-Out
Precis provided design services for an existing office building renovation into a new corporate headquarters for Lannett Company, a growing general pharmaceutical manufacturing company.
The new space included renovations on two floors, reusing the majority of open office furniture that existed, while supplementing with new furniture and finishes. New private offices and conference rooms were added, and new collaboration areas with soft seating and new lighting and technology were introduced.
The highlight feature of the new headquarters is an open multipurpose breakroom/think tank space centrally located to the surrounding office area and designed to facilitate various program functions throughout the day. It is the heartbeat of the office. In addition, the reception/lobby area is designed to be like a small business and innovation center with conference rooms, soft seating workspaces, and a customer experience product showcase area.
Formic Acid Vapor Bulk Delivery System
Developed as a beta site for larger scale deployment in manufacturing settings, the new Formic Acid Vapor Bulk Delivery System project was developed in collaboration with the client’s process engineers. The project encompassed modifications within an existing research and development (R&D) operations center to create base facilities for the preparation, generation, and distribution of formic acid vapor to process chambers within multiple microchip bonding units. The system initially serves four bonders and is expandable to 11 within the development cleanroom area.
Precis provided architectural and engineering services across all disciplines for design and construction administration. Critical components for service have included initial process reviews of the client’s concepts and collaborative development of system details along with facility support to promote optimal function and user safety.
Additionally, Precis provided design services to the client for complete relocation and fit-out for a new Tier 3 level data center.
